ʻIke ʻia ka holoi ʻana o ka gene Phf21b me ka maʻi kanesa a me ke kaumaha. Ke hōʻike nei ka noiʻi hou i kēia manawa he hana koʻikoʻi ka hōʻike ʻana o kēia gene i ka hoʻokaʻawale ʻana o ka neural stem cell a me ka ulu ʻana o ka lolo.
ʻO kahi noiʻi hou i paʻi ʻia ma ka puke pai Genes and Development ma 20 Malaki 2020, e pili ana i ka hana o ka protein Phf21b i hoʻopili ʻia e PHF21B ka gene i ka hoʻokaʻawale ʻana o nā pūnaʻi neural. Eia kekahi, ʻo ka holoi ʻana o Phf21b i loko o vivo, ʻaʻole wale i kaohi ʻana i ka ʻokoʻa cell neural akā ua hopena pū kekahi i nā cell progenitor cortical e hana i nā pōʻai cell wikiwiki. ʻO ke aʻo ʻana i kēia manawa e nā mea noiʻi ma ke Kulanui o ka Mōʻīwahine o Belfast e hōʻike ana i ka manawa kūpono o ka protein phf21b i mea nui no ka hoʻokaʻawale ʻana o ka neural stem cell i ka wā o ka hoʻomohala ʻana.1. ʻO ke kuleana o Phf21b i ka hoʻokaʻawale ʻana o nā pūnaewele neural stem e hōʻike ana i kahi hana koʻikoʻi i ka hoʻomaopopo ʻana i ka neurogenesis i ka hoʻomohala ʻana i nā cell cortical a e hoʻonui i ko mākou ʻike i ke kaʻina hana paʻakikī. ka lolo ka hoʻomohala ʻana a me kāna hoʻoponopono i ʻike ʻole ʻia a hiki i kēia manawa e pili ana i ka hoʻololi ʻana ma waena o ka hoʻonui a me ka ʻokoʻa i ka wā neurogenesis.
Ka moʻolelo o ka PHF21B Hiki ke hoʻohālikelike ʻia ke ʻano i hoʻomaka ma kahi o ʻelua mau makahiki i hala aku nei i ka makahiki 2002, ʻike ʻia nā haʻawina PCR manawa maoli ʻo ka holoi ʻana o 22q.13 māhele o ka chromosome 22 he maikaʻi ʻole ka prognosis i ka maʻi maʻi waha.2. Ua hōʻoia hou ʻia kēia i kekahi mau makahiki ma hope o 2005 i ka manawa ʻo Bergamo et al3 Ua hōʻike ʻia me ka hoʻohana ʻana i nā loiloi cytogenetic e pili ana ka holoi ʻana i kēia māhele o ka chromosome 22 me ke poʻo a me ka ʻāʻī. maʻi pū.
Ma kahi kokoke i hoʻokahi ʻumi makahiki ma hope o 2015, ua ʻike ʻo Bertonha a me nā hoa hana i ka gene PHF21B ma muli o ka holoi ʻana i ka ʻāina 22q.13.4. Ua hoʻopaʻa ʻia nā holoi ʻana i kahi hui o nā poʻo a me ka ʻāʻī squamous cell carcinoma maʻi a me ka hōʻemi ʻana o ka PHF21B i hoʻoili ʻia i ka hypermethylation e hōʻoia ana i kāna kuleana ma ke ʻano he ʻano suppressor tumor. I hoʻokahi makahiki ma hope o 2016, ua hōʻike ʻo Wong et al i ka hui ʻana o kēia ʻano i loko o ke kaumaha ma muli o ke koʻikoʻi kiʻekiʻe e hōʻemi ana i ka hōʻike ʻana o PHF21B. 5.
ʻO kēia noiʻi a me ka noiʻi hou aku e pili ana i nā loiloi huaʻōlelo o phf21b i ka manawa a me ka manawa e hoʻomākaukau i ke ala no ka hoʻomaʻamaʻa mua ʻana a me ka mālama maikaʻi ʻana i nā maʻi neurological e like me ke kaumaha, ka lohi o ka noʻonoʻo a me nā mea ʻē aʻe. ka lolo nā maʻi pili e like me Alzheimer a me Parkinson.
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E hoʻomaopopo ':
1. Basu A, Mestres I, Sahu SK, et al 2020. Phf21b imprints i ka spatiotemporal epigenetic switch pono no ka neural stem cell differentiation. Genes & Dev. 2020. DOI: https://doi.org/10.1101/gad.333906.119
2. Reis, PP, Rogatto SR, Kowalski LP et al. Hoʻomaopopo ka nui o ka PCR manawa maoli i kahi ʻāpana koʻikoʻi o ka holoi ʻana ma 22q13 e pili ana i ka prognosis i ka maʻi maʻi waha. Oncogene 21: 6480-6487, 2002. DOI: https://doi.org/10.1038/sj.onc.1205864
3. Bergamo NA, da Silva Veiga LC, dos Reis PP et al. Hōʻike nā loiloi cytogenetic maʻamau a me ka molecular i ka loaʻa ʻana o ka chromosomal a me nā poho i hoʻopili ʻia me ke ola ʻana i nā maʻi maʻi maʻi poʻo a me ka ʻāʻī. Clin. Ka maʻi maʻi Res. 11: 621-631, 2005. Loaʻa ma ka pūnaewele ma https://clincancerres.aacrjournals.org/content/11/2/621
4. Bertonha FB, Barros Filho MdeC, Kuasne H, dos Reis PP, da Costa Prando E., Munoz JJAM, Roffe M, Hajj GNM, Kowalski LP, Rainho CA, Rogatto SR. ʻO PHF21B ma ke ʻano he moho hoʻopaʻa ʻana i ka maʻi tumora ma ke poʻo a me ka ʻāʻī squamous cell carcinomas. Molec. ʻO Oncol. 9: 450-462, 2015. DOI: https://doi.org/10.1016/j.molonc.2014.09.009
5. Wong M, Arcos-Burgos M, Liu S et al. ka PHF21B pili ka gene me ke kaumaha nui a hoʻololi i ka pane pilikia. Mol Psychiatry 22, 1015-1025 (2017). DOI: https://doi.org/10.1038/mp.2016.174
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