ʻO nā Androgens e like me ka testosterone e nānā maʻalahi ʻia e like me ka hana ʻana i ka huhū, impulsivity a me nā ʻano antisocial. Eia naʻe, hoʻoikaika nā androgens i ka hana ma kahi ala paʻakikī e komo pū ana me ka hoʻolaha ʻana i nā ʻano pro- a me nā ʻano antisocial, me kahi ʻano hana e hoʻonui ai i ke kūlana kaiapili.1. Ma kahi haʻawina e hoʻāʻo ana i ka hopena koʻikoʻi o ka testosterone ma ka hana, ʻoi aku ka maikaʻi o ka hui testosterone e uku nui i nā makana maikaʻi i ʻike ʻia ma kahi hoʻokolohua ʻoiai ʻoi aku ka paʻakikī i ka hoʻopaʻi ʻana i nā makana maikaʻi ʻole.1. Eia kekahi, ʻaʻole i ʻike ʻia aia nā hōʻike e hōʻike ana i ka emi ʻana o nā androgens serum e like me ka ʻike ʻia i ka piʻi ʻana o ka makahiki he kumu pilikia nui ia no nā maʻi neurodegenerative, a ʻo ka hopena o ka ʻano ε4 o ka ʻano ApoE i nā ʻiole (e hoʻemi ana i ka hoʻomanaʻo a me ke aʻo ʻana i ka spatial) Ua pale ʻia e ka hoʻohana ʻana i nā androgens2.
A me nā hōʻailona ʻO nā hormones steroid e hoʻonāukiuki i ka nuklea androgen receptor a hoʻoulu i ka transcription o nā genes e kumu i ka ulu ʻana o nā hiʻohiʻona kāne lua.3. Hoʻokumu ʻia nā Androgens i ka hopena ma o ka steroidogenesis kahi kaʻina hana multi-step e hoʻohuli ana i ka cholesterol i nā hormone steroid like ʻole.4. ʻO nā hormones steroid endogenous kaulana me ka agonism nui o ka receptor androgen he testosterone a me kāna metabolite dihydrotestosterone.3. ʻO nā androgens endogenous ʻē aʻe i manaʻo ʻia he agonists nāwaliwali a he mau mua i ka steroidogenesis o testosterone. ʻO Testosterone kahi pani no ka enzyme aromatase, ʻaʻole like me ka dihydrotestosterone i manaʻo ʻia he "maʻemaʻe" androgen, kahi e hoʻololi ʻia ai i ka estrogen estradiol ikaika.5, no laila e ho'āʻo kēiaʻatikala e hoʻokaʻawale i nā hopena androgenic i ka mammalian ka lolo mai ka hōʻailona estrogenic indirect mai ka metabolism o ka testosterone.
ʻIke ʻia ʻo Estradiol i nā hopena neuroprotective a ke noiʻi ʻia nei ma ke ʻano he lapaʻau no AlzheimerʻO ka maʻi, akā ua hoʻoholo ʻia ʻo ka hōʻailona androgenic o androgens i loko o ka physiological concentrations (me ka ʻole o ka metabolism i ka estrogens) he neuroprotective kekahi.6. Hoʻemi ʻia ka hopena apoptotic induced i nā neurones kanaka moʻomeheu i ka wā i hui pū ʻia me ka testosterone a me kahi mea hoʻopaneʻe aromatase, a i ka wā i hui pū ʻia me ka non-aromatizable androgen mibolerone.6, ʻaʻole pono ka metabolism o ka testosterone i ka estradiol no kāna mau hopena neuroprotective. Eia kekahi, i ka wā i hui pū ʻia ai ka testosterone me kahi antiandrogen (flutamide), ʻaʻohe ona hopena pale i nā neurones kanaka.6 e hōʻike ana i ka hōʻailona androgenic he neuroprotective.
ʻO ka hoʻohana ʻana i ka nui kiʻekiʻe (5mg / kg e like ana me 400mg i kahi kanaka makua 80kg) androgens (me ka testosterone propionate a me ka ester unspecified o dihydrotestosterone) i nā ʻiole e hoʻemi i ka dopamine i ka hypothalamus a me amygdala, me ka ʻole o ka pili ʻana i ka norepinephrine a me ke serotonin, a me ka hopena ʻike ʻole. ma kekahi ka lolo wahi7. Eia kekahi, hoʻololi nā androgens i ka hana ma o ka hoʻopili ʻana i ka ʻōnaehana mesocorticolimbic8. Hoʻopili ʻia ka ʻōnaehana mesocorticolimbic i ke aʻo ʻana i ka uku (a no laila ke hoʻohui ʻana), no laila e hoʻopili ai i ka ʻano9.
ʻO ka hoʻokele Testosterone i loko o ka nucleus accumbens o nā ʻiole ke kumu o ka hoʻonohonoho ʻana i ka wahi ma muli o ka hui ʻana o ka wahi me ka uku (e like me ka hopena o ka dopamine hoʻokuʻu i nā lāʻau lapaʻau)8. Hoʻopau ʻia kēia pane i nā androgens ke hoʻopau ʻia kahi dopamine D1 a me D2 Hoʻohana pū ʻia ka mea kūʻē i ka receptor antagonist8, e hōʻike ana i ka mana o ka testosterone ma ka hōʻailona dopamine. Hāʻawi nā moa kāne ʻōpio i nā ʻano ʻai testosterone pecked o ka waihoʻoluʻu maʻamau a ʻoi aku ka nui o ka hoa e ʻimi ana i ka hoʻomau ʻaʻole like me nā moa mālama ʻia i placebo i hōʻike i ka maʻalahi o ka hana.8. ʻIke ʻia ka Testosterone i ka hiki ke hoʻololi i ka hoʻolālā pane inā ʻaʻole maikaʻi, kākoʻo ʻia e ka hopena hoʻomau-hoʻemi o ka mālama antiandrogen i nā moa.8.
ʻAʻole i emi ka hoʻomanawanui ʻana o nā ʻiole Gonadectomised i nā hana hoʻomaʻamaʻa operant a hōʻike i kahi hemahema o ka hoʻomanaʻo hana ke hoʻohālikelike ʻia me nā ʻiole gonadectomised i mālama ʻia e ka testosterone.8. Eia kekahi, ʻo ka hoʻohaʻahaʻa nui ʻana i ka agonism receptor androgen e like me ka antiandrogens e hoʻemi i ka hana hoʻokō, ka mana cognitive, nānā a me ka visuospatial hiki, me ka hoʻohaʻahaʻa ʻana i ka mea hina ma nā wahi o ka cortex prefrontal.8. Hoʻonui ʻia ka nui o ka spine dendritic i ka ʻōnaehana limbic o nā ʻiole i mālama ʻia me nā kiʻekiʻe o ka testosterone. I ka medial prefrontal cortex, hoʻonui ka dihydrotestosterone i ka hoʻokumu ʻana o ka spine dendritic8, e hōʻike ana i ka mea nui no nā androgens i ka ka lolo.
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E hoʻomaopopo ':
- Dreher J., Dunne S., et al 2016. Testosterone kumu pro- a me antisocial hana Proceedings o ka National Academy of Sciences (PNAS) Oct 2016, 113 (41) 11633-11638; DOI: https://doi.org/10.1073/pnas.1608085113
- Jordan, CL, & Doncarlos, L. (2008). Androgens i ke olakino a me ka maʻi: kahi ʻike. Hormone a me ana, 53(5), 589–595. DOI: https://doi.org/10.1016/j.yhbeh.2008.02.016
- DJ kanaka lima lima. Androgen Physiology, Pharmacology, Hoʻohana a hoʻohana hewa. [Hoʻohou 2020 ʻOkakopa 5]. Ma: Feingold KR, Anawalt B, Boyce A, a me nā mea hoʻoponopono. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Loaʻa mai: https://www.ncbi.nlm.nih.gov/books/NBK279000/
- Encyclopedia of Neuroscience, 2009. Steroidogenesis. Loaʻa ma ka pūnaewele ma https://www.sciencedirect.com/topics/medicine-and-dentistry/steroidogenesis
- Hoʻohui ʻia o nā lāʻau kūʻai maikaʻi loa, 2016. Aromatase. Loaʻa ma ka pūnaewele ma https://www.sciencedirect.com/topics/chemistry/aromatase
- Hammond J, Le Q, Goodyer C, Gelfand M, Trifiro M, LeBlanc A. Testosterone-mediated neuroprotection ma o ka androgen receptor i nā neurons mua o ke kanaka. J Neurochem. 2001 Iun;77(5):1319-26. PMID: 11389183. DOI: https://doi.org/10.1046/j.1471-4159.2001.00345.x
- ʻO Vermes I, Várszegi M, Tóth EK, Telegdy G. Ka hana o nā steroid androgenic ma nā neurotransmitters lolo i nāʻiole. Neuroendocrinology. 1979;28(6):386-93. DOI: https://doi.org/10.1159/000122887
- Tobiansky D., Wallin-Miller K., ¶ AL 2018. Hoʻoponopono Androgen o ka Mesocorticolimbic System a me ka hana hoʻokō. Imua. Endocrinol., 05 Iune 2018. DOI: https://doi.org/10.3389/fendo.2018.00279
- Komisina ʻEulopa 2019. Nā Huaʻimi noiʻi CORDIS EU - Pūnaehana Mesocorticolimbic: anatomy hana, lāʻau-evoked synaptic plasticity & behavioral correlates of Synaptic Inhibition. Loaʻa ma ka pūnaewele ma https://cordis.europa.eu/project/id/322541
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