ʻO kahi ala hou e 'hoʻihoʻi hou' i nā lāʻau lapaʻau e kū nei no COVID-19

ʻO kahi hui pū ʻana o ka biological a me ka computational approach e aʻo ai i nā pilina protein-protein (PPIs) ma waena o ka viral a me nā protein host i mea e ʻike ai a hoʻohana hou i nā lāʻau lapaʻau no ka mālama pono ʻana o COVID-19 a me nā maʻi ʻē aʻe kekahi..

ʻO nā hoʻolālā maʻamau e hoʻoponopono i nā maʻi viral e pili ana i ka hoʻolālā ʻana i nā lāʻau anti-viral a me ka hoʻomohala ʻana i nā kano. I ka pilikia i hiki ʻole i kēia manawa, ke alo nei ka honua ma muli o Covid-19 ma muli o SARS-CoV-2 mea hoʻomaʻi, nā hualoaʻa mai nā ʻaoʻao ʻelua ma luna nei me he mea lā mamao loa e hāʻawi i nā hopena manaʻolana.

Ua hoʻohana ʻia kahi hui o nā mea noiʻi honua (1) i kahi ala hou (e pili ana i ke ʻano o ka hui ʻana o nā maʻi me ka poʻe hoʻokipa) no ka "hana hou" i nā lāʻau lapaʻau e ʻike nei i nā lāʻau hou i lalo o ka hoʻomohala ʻana, hiki ke kōkua i ke kaua ʻana i ka maʻi COVID-19. I mea e hoʻomaopopo ai pehea e launa pū ai ʻo SARS-CoV-2 me nā kānaka, ua hoʻohana ka poʻe noiʻi i ka hui pū ʻana o nā ʻenehana biological a me ka computational e hana i kahi "palapala" o nā protein kanaka i hui pū ʻia e nā protein viral a hoʻohana i ka maʻi i ke kanaka. Ua hiki i nā mea noiʻi ke ʻike ma mua o 300 mau protein kanaka e launa pū me nā protein viral 26 i hoʻohana ʻia i ke aʻo ʻana (2). ʻO ka hana aʻe, ʻo ia ka ʻike ʻana i kahi o nā lāʻau lapaʻau e kū nei a me nā mea i kūkulu ʻia e "hana hou ʻia"e mālama i ka maʻi COVID-19 ma ka huli ʻana i kēlā mau protein kanaka.

Ua alakaʻi ka noiʻi i ka ʻike ʻana i ʻelua papa o nā lāʻau lapaʻau i hiki ke mālama maikaʻi a hōʻemi i ka maʻi COVID-19: nā mea hoʻopiʻi unuhi protein e komo pū ana me zotatifin a me ternatin-4/plitidepsin, a me nā lāʻau lapaʻau ke kuleana no ka modulation protein o Sigma1 a me Sigma 2 receptors i loko o ka. pūnaewele me ka progesterone, PB28, PD-144418, hydroxychloroquine, nā lāʻau antipsychotic haloperidol a me cloperazine, siramesine, kahi lāʻau antidepressant a me ka anti-anxiety lāʻau, a me nā antihistamines clemastine a me cloperastine.

ʻO nā mea paʻa unuhi protein, ʻike ʻia ka hopena antiviral ikaika loa i loko o ka vitro e kūʻē iā COVID-19 me zotatifin, i kēia manawa i nā hoʻokolohua lapaʻau no ka maʻi kanesa, a me ka ternatin-4/plitidepsin, i ʻae ʻia e FDA no ka mālama ʻana i ka myeloma lehulehu.

Ma waena o nā lāʻau lapaʻau e hoʻololi i ka Sigma1 a me Sigma2 receptors, ka antipsychotic haloperidol, i hoʻohana ʻia e mālama i ka schizophrenia, hōʻike i ka hana antiviral e kūʻē iā SARS-CoV-2. ʻElua mau anti-histamine ikaika, clemastine a me cloperastine, i hōʻike pū i ka hana antiviral, e like me PB28. ʻO ka hopena anti-viral i hōʻike ʻia e PB28 ma kahi o 20 mau manawa ʻoi aku ka nui ma mua o ka hydroxychloroquine. ʻO ka Hydroxychloroquine, ma ka ʻaoʻao ʻē aʻe, ua hōʻike ʻo ia, i ka hoʻohui ʻana i nā mea hoʻokipa Sigma1 a me -2, pili pū kekahi i kahi protein i kapa ʻia ʻo hERG, i ʻike ʻia no ka hoʻoponopono ʻana i ka hana uila i loko o ka puʻuwai. Hiki i kēia mau hopena ke kōkua i ka wehewehe ʻana i nā pilikia e pili ana i ka hoʻohana ʻana i ka hydroxychloroquine a me kāna mau derivatives ma ke ʻano he lāʻau lapaʻau no COVID-19.

ʻOiai ua hoʻopuka nā haʻawina in vitro i ʻōlelo ʻia ma luna nei i nā hopena hoʻohiki, ʻo ka 'hōʻoia o ka pudding' e hilinaʻi ʻia i ke ʻano o ka holo ʻana o kēia mau molekala lāʻau lapaʻau i nā hoʻokolohua lapaʻau a alakaʻi i kahi lāʻau lapaʻau no COVID-19 koke. ʻO ka ʻokoʻa o ka haʻawina ʻo ia ka hoʻonui ʻana i ko mākou ʻike i ko mākou ʻike kumu e pili ana i ka pili ʻana o ka maʻi me ka mea hoʻokipa e alakaʻi ana i ka ʻike ʻana i nā protein kanaka e pili ana me nā protein viral a me ka wehe ʻana i nā pūhui i ʻike ʻole ʻia e aʻo i kahi hoʻonohonoho viral.

ʻO kēia ʻike i hōʻike ʻia mai kēia noiʻi ʻaʻole i kōkua wale i nā ʻepekema e ʻike koke i nā moho lāʻau hoʻohiki no ka ʻimi ʻana i nā hoʻokolohua lapaʻau, akā hiki ke hoʻohana ʻia e hoʻomaopopo a manaʻo i ka hopena o nā lāʻau lapaʻau e hana nei i loko o ke keʻena a hiki ke hoʻonui ʻia no ka ʻike ʻana i ka lāʻau lapaʻau e kūʻē i nā mea ʻē aʻe. nā maʻi viral a me nā maʻi ʻole.

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E hoʻomaopopo ':

1. ʻO ka Institut Pasteur, 2020. E hōʻike ana pehea e kāʻili ai ʻo SARS-COV-2 i nā pūnaewele kanaka; Nā kuhikuhi i nā lāʻau lapaʻau me ka hiki ke hakakā iā COVID-19 a me kahi lāʻau lapaʻau e kōkua i kona ulu ʻana. NĀ PAʻI PAʻI I kau ʻia ma 30 ʻApelila 2020. Loaʻa ma ka pūnaewele ma https://www.pasteur.fr/en/research-journal/press-documents/revealing-how-sars-cov-2-hijacks-human-cells-points-drugs-potential-fight-covid-19-and-drug-aids-its Loaʻa i ka 06 Mei 2020.

2. Gordon, DE et al. 2020. Hōʻike ʻia kahi palapala hoʻopili protein SARS-CoV-2 i nā pahuhopu no ka hoʻohana hou ʻana i ka lāʻau. Nature (2020). DOI: https://doi.org/10.1038/s41586-020-2286-9

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