Ua hoʻomohala nā kānaka ʻepekema i kahi kahua bioprinting 3D e hōʻuluʻulu i nā ʻiʻo neural kanaka hana . Ulu nā cell progenitor i loko o nā ʻiʻo i paʻi ʻia e hana i nā kaapuni neural a hana i nā pilina hana me nā neurons ʻē aʻe e hoʻohālike ana i nā ʻiʻo lolo maoli . He holomua koʻikoʻi kēia i ka ʻenekinia ʻiʻo neural a me ka ʻenehana bioprinting 3D. Hiki ke hoʻohana ʻia kēlā mau ʻiʻo neural bioprinted i ke kumu hoʻohālike ʻana i nā maʻi kanaka (e like me Alzheimer's, Parkinson's etc.) i hana ʻia ma muli o ka hōʻino ʻia o nā pūnaewele neural. Pono kekahi noiʻi ʻana i ka maʻi o ka lolo e hoʻomaopopo pehea e hana ai nā pūnaewele neural kanaka.
ʻO ka bioprinting 3D kahi hana hoʻohui kahi i hui pū ʻia ai ka biomaterial kūlohelohe a synthetic paha (bioink) me nā cell ola a paʻi ʻia, papa-ma-papa, i loko o nā ʻano ʻano ʻekolu-dimensional e like me nā ʻiʻo maoli. Ulu nā cell i loko o ka bioink a ulu nā ʻano e hoʻohālike i nā ʻiʻo a i ʻole nā ʻano maoli. Ua loaʻa i kēia ʻenehana nā noi i ka lāʻau lapaʻau regenerative no ka bioprinting o nā cell, nā ʻiʻo a me nā ʻano a ma ka noiʻi ʻana ma ke ʻano he kumu hoʻohālike e aʻo ai i ke kino kanaka in vitro , ʻoiai ka ʻōnaehana nerve kanaka .
Ke kū nei ke aʻo ʻana i ka ʻōnaehana nerve kanaka i nā palena ma muli o ka loaʻa ʻole o nā laʻana mua. He kōkua nā hiʻohiʻona holoholona akā ʻeha lākou i nā ʻokoʻa kikoʻī o nā ʻano like ʻole no laila ke koʻikoʻi o nā hiʻohiʻona in vitro o ka ʻōnaehana nerve kanaka e noiʻi i ke ʻano o ka hana ʻana o nā pūnaewele neural kanaka i ka loaʻa ʻana o nā lāʻau lapaʻau no nā maʻi i hoʻopili ʻia i ka hemahema o nā pūnaewele neural.
Ma kahi noiʻi hou, ua koho nā kānaka noiʻi i ka fibrin hydrogel (i loko o ka fibrinogen a me ka thrombin) ma ke ʻano he bioink kumu a ua hoʻolālā e paʻi i kahi ʻano papa kahi e hiki ai i nā cell progenitor ke ulu a hana i nā synapses i loko a ma waena o nā papa, akā ua hoʻololi lākou i ke ʻano o ka hoʻopili ʻia ʻana o nā papa i ka wā o ka paʻi ʻana. Ma kahi o ke ʻano kuʻuna o ka hoʻopili ʻana i nā papa ma ke ʻano kū pololei, ua koho lākou e paʻi i nā papa ma ka ʻaoʻao o kekahi ma ka ʻaoʻao ākea. ʻIke ʻia, ua hana kēia i ka ʻokoʻa. Ua ʻike ʻia kā lākou kahua bioprinting 3D e hōʻuluʻulu i nā ʻiʻo neural kanaka hana . ʻO kahi hoʻomaikaʻi ma luna o nā kahua ʻē aʻe, ʻo ka ʻiʻo neural kanaka i paʻi ʻia e kēia kahua i hoʻokumu i nā pūnaewele neural a me nā pilina hana me nā neurons ʻē aʻe a me nā cell glial i loko a ma waena o nā papa. ʻO kēia ka hihia mua o ia ʻano a he ʻanuʻu koʻikoʻi i mua i ka ʻenekinia ʻiʻo neural. ʻO ka synthesis Laboratory o nā ʻiʻo nerve e hoʻohālike ana i ka lolo i ka hana he mea hoihoi. E kōkua maoli kēia holomua i nā kānaka noiʻi i ke kumu hoʻohālike ʻana i nā maʻi kanaka o ka lolo i hana ʻia ma muli o ka pūnaewele neural i hoʻopilikia ʻia e hoʻomaopopo maikaʻi i ke ʻano no ka loaʻa ʻana o kahi lāʻau lapaʻau.
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E hoʻomaopopo ':
- Cadena M., ¶ AL 2020. 3D Bioprinting o nā ʻiʻo neural. Nā Mea Hana Ola Loa Loa 10, Puka 15 2001600. DOI: https://doi.org/10.1002/adhm.202001600
- Yan Y., ¶ AL 2024. 3D bioprinting o kanaka nā kino neural me ka pilina hana. Pūnaehana Pūnaewele Pūnaewele| Volume 31, Puka 2, P260-274.E7, Pepeluali 01, 2024. DOI: https://doi.org/10.1016/j.stem.2023.12.009
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