Ua hoʻomohala ka poʻe ʻepekema i kahi paepae bioprinting 3D e hōʻuluʻulu i ka hana kanaka neural tissues. Ke ulu nei nā pūnaewele progenitor i loko o nā ʻiʻo i paʻi ʻia e hana i nā neural circuits a hana i nā pilina hana me nā neurons ʻē aʻe e like me ke ʻano kūlohelohe. ka lolo nā lole. He holomua koʻikoʻi kēia i ka ʻenehana neural tissue a me ka ʻenehana bioprinting 3D. Hiki ke hoʻohana ʻia ia mau ʻiʻo neural bioprinted i ka hoʻohālike kanaka nā maʻi (e like me Alzheimer's, Parkinson's etc.) i hoʻokumu ʻia ma muli o ka hōʻino ʻana o nā pūnaewele neural. Kekahi noiʻi o ka maʻi o ka lolo pono e hoʻomaopopo pehea ka kanaka hana nā neural network.
3D bioprinting He kaʻina hana hoʻohui kahi e hui pū ʻia ai ka biomaterial kūlohelohe a i ʻole synthetic (bioink) me nā keena ola a paʻi ʻia, papa-a-papa, i loko o nā ʻano kino-like-ʻekolu-dimensional. Ke ulu nei nā pūnaewele i loko o ka bioink a hoʻomohala nā hale e hoʻohālike i ka ʻiʻo maoli a i ʻole ke kino. Ua loaʻa kēia ʻenehana i nā noi ma regenerative lāʻau lapaʻau no ka paʻi ʻia ʻana o nā pūnaewele, ʻiʻo a me nā ʻāpana a ma ka noiʻi ʻana i kumu hoʻohālike e aʻo ai kanaka kino ma ka vitro, kikoʻī kanaka ʻōnaeʻa nūnū.
Haʻawina o kanaka Ke alo nei ka ʻōnaehana nerve i nā palena ma muli o ka loaʻa ʻole o nā laʻana mua. He mea kōkua nā kumu hoʻohālike holoholona akā loaʻa i nā ʻokoʻa like ʻole o nā ʻano like ʻole no laila ke koʻikoʻi o ma ka vitro nā kumu hoʻohālike o ka kanaka nenoaiu e noiʻi pehea ka kanaka Hoʻohana nā neural network i ka ʻimi ʻana i nā lāʻau lapaʻau no nā maʻi i pili i ka hōʻino ʻana o nā ʻupena neural.
kanaka Ua paʻi ʻia nā ʻiʻo neural i ka 3D i ka wā ma mua me ka hoʻohana ʻana i nā cell stem akā ʻaʻole i loaʻa kēia mau neural network formation. ʻAʻole i hōʻike ʻia ka ʻiʻo i paʻi ʻia i nā pilina ma waena o nā cell no nā kumu he nui. Ua lanakila kēia mau hemahema i kēia manawa.
Ma kahi noiʻi hou, nā mea noiʻi koho i ka fibrin hydrogel (ʻo ia ka fibrinogen a me ka thrombin) ma ke ʻano he bioink kumu a ua hoʻolālā ʻia e paʻi i kahi ʻano papa i hiki ai i nā cell progenitor ke ulu a hana i nā synapses i loko a ma waena o nā papa, akā ua hoʻololi lākou i ke ʻano o ka hoʻopaʻa ʻana o nā papa i ka wā paʻi. Ma kahi o ke ʻano kuʻuna o ka hoʻopaʻa ʻana i nā papa ma ke kūpaʻa, ua koho lākou e paʻi i nā papa ma ka ʻaoʻao o kahi ʻē aʻe. ʻIke ʻia, ua ʻokoʻa kēia. Ua ʻike ʻia kā lākou 3D bioprinting platform e hōʻuluʻulu i ka hana kanaka kino neural. ʻO ka hoʻomaikaʻi ʻana ma luna o nā paepae ʻē aʻe e kū nei, ka kanaka ʻO ka ʻiʻo neural i paʻi ʻia e kēia kahua i hoʻokumu ʻia i nā ʻupena neural a me nā pilina hana me nā neurons ʻē aʻe a me nā cell glial i loko a ma waena o nā papa. ʻO kēia ka hihia mua loa a he hana koʻikoʻi i mua i ka ʻenehana neural tissue. ʻO ka hoʻohuihui ʻana o nā ʻiʻo nerve e like me ka lolo i ka hana he leo hoihoi. E kōkua maoli kēia holomua i ka poʻe noiʻi i ka hoʻohālike kanaka nā maʻi o ka lolo i hoʻokumu ʻia ma muli o ka neural network impaired e hoʻomaopopo maikaʻi i ke ʻano o ka loaʻa ʻana o kahi lapaʻau hiki.
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E hoʻomaopopo ':
- Cadena M., ¶ AL 2020. 3D Bioprinting o nā ʻiʻo neural. Nā Mea Hana Ola Loa Loa 10, Puka 15 2001600. DOI: https://doi.org/10.1002/adhm.202001600
- Yan Y., ¶ AL 2024. 3D bioprinting o kanaka nā kino neural me ka pilina hana. Pūnaehana Pūnaewele Pūnaewele| Volume 31, Puka 2, P260-274.E7, Pepeluali 01, 2024. DOI: https://doi.org/10.1016/j.stem.2023.12.009
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