Ka hopena maikaʻi ʻole o ka Fructose ma ka ʻōnaehana pale

Ua hōʻike ʻia ma kahi noiʻi hou e hiki i ka hoʻonui ʻana i ka ʻai ʻana o ka fructose (kō hua) ke loaʻa ka hopena maikaʻi ʻole i ka pale ʻana o ka maʻi. Hoʻohui hou kēia i ke kumu e makaʻala ai i ka ʻai ʻana o ka fructose i ka ʻai, e pili ana i kona hopena i ka ʻōnaehana pale.

ʻO Fructose kahi kō maʻalahi i loaʻa i nā kumu he nui e like me nā huaʻai, ke kō pākaukau, ka meli a me ka hapa nui o nā ʻano syrup. Ua hōʻike ka ʻai ʻana o Fructose i kahi piʻi mau, ʻo ia hoʻi ma muli o ka ʻai ʻana i ka nui o ka syrup kulina fructose kiʻekiʻe, ʻoi aku hoʻi ma nā ʻāina Komohana. Ua ʻike ʻia ʻo Fructose e pili ana me ka momona, ka maʻi diabetes type 2 a me ka maʻi ate momona ʻole ^1. ʻO kēia paha ma muli o ka fructose i loko o ke kino e hana ana i nā ala metabolic like ʻole i hoʻohālikelike ʻia me ka glucose a ʻoi aku ka liʻiliʻi o ka hoʻoponopono ʻia ma mua o ka glucose; ua manaʻo ʻia kēia e alakaʻi i ka hoʻonui ʻana i ka synthesis o nā waikawa momona e alakaʻi ana i nā hopena olakino maikaʻi ʻole ^2. Eia kekahi, ma anecdotal, ʻoi aku ka "maʻa" o ke kanaka a ua maʻa i ka glucose e hōʻike ana i ka lawelawe maikaʻi ʻole o ka fructose.

Ua hōʻike ʻia kahi noiʻi hou i nā ʻano hana e hoʻopilikia ai ka fructose i nā hana hewa i loko o nā cell immune ^1. Ke noiʻi nei kēia noiʻi i nā hopena o ka fructose ma nā cell immune, ʻoiai nā monocytes. Mālama nā Monocytes i nā kānaka mai ka hoʻouka kaua microbial a he ʻāpana o ka ʻōnaehana pale kūlohelohe ^3. Pale ka ʻōnaehana pale kūlohelohe i nā pathogens e komo i ke kino ^4. Hoʻonui nā hopena maikaʻi ʻole o ka fructose ma nā cell immune i ka papa inoa o nā hopena olakino maikaʻi ʻole o ka fructose, e hōʻike ana ʻaʻole hiki i ka ʻai ʻana i ka fructose i ka meaʻai ke kūpono no ke olakino pale maikaʻi loa. Eia nō naʻe, he mea nui e ʻōlelo ʻaʻole hiki ke hoʻololi ʻia ka fructose a me ka hua no ka mea he nui nā kumu fructose e like me ka syrup kulina fructose kiʻekiʻe ʻaʻohe meaʻai pono, a aia paha kekahi mau pono o ka ʻai ʻana i nā hua kikoʻī e like me ka fiber a me ka lawe ʻana i nā micronutrient e ʻoi aku ka nui ma mua o nā pilikia o ka fructose pili.

Ua hōʻike nā monocytes i mālama ʻia me ka fructose i nā pae haʻahaʻa o ka glycolysis (kahi ala metabolic e loaʻa ai ka ikehu no nā cell e hoʻohana ai) ʻo ia hoʻi nā pae o ka glycolysis mai ka fructose ua aneane like me ka glycolysis i loko o nā cell i mālama ʻia me ke kō ʻole ^1. Eia kekahi, ʻoi aku ka kiʻekiʻe o ka hoʻohana ʻana o ka oxygen i nā monocytes i mālama ʻia me ka glucose ^1. ʻOi aku ka hilinaʻi o nā monocytes i ulu ʻia me ka Fructose i ka phosphorylation oxidative ma mua o nā monocytes i ulu ʻia me ka glucose ^1. Hoʻopuka ka phosphorylation oxidative i ka stress oxidative ma o ka hoʻokumu ʻana o nā radical free ⁵.

Ua hōʻike nā monocytes i mālama ʻia me ka Fructose i ka nele o ka hoʻololi metabolic ^1. Ua hoʻonui pū ka mālama ʻana me ka Fructose i nā māka mumū e like me nā interleukins a me ka tumor necrosis factor ma mua o ka mālama ʻana i ka glucose ^1. Kākoʻo ʻia kēia e ka ʻike ʻana e hoʻonui ka fructose dietary i ka mumū i nā ʻiole ^1. Eia kekahi, ʻaʻole i maʻalahi ka metabolically monocytes i mālama ʻia me ka fructose a hilinaʻi ʻia i ka metabolism oxidative no ka ikehu ^1. Eia naʻe, ʻaʻole i hoʻopilikia maikaʻi ʻia nā T-cells (kekahi cell immune) e ka fructose ma ke ʻano o nā māka mumū, akā ua ʻike ʻia ka fructose e hāʻawi i nā maʻi e like me ka momona, ka maʻi ʻaʻai a me ka maʻi momona ʻole o ke akepaʻa a hoʻonui kēia ʻike hou i ka papa inoa o nā pōʻino hiki o ka fructose ma o ka hoʻoulu ʻana i nā hopena maikaʻi ʻole ma ka ʻōnaehana pale ^1. Hōʻike pū kēia noiʻi hou i nā hopena oxidative-stress a me nā hopena mumū o ka fructose a hōʻike i ka nāwaliwali o nā cell immune koʻikoʻi: nā monocytes, i ka wā e hoʻohana ai i ka fructose no ka ikehu ^1. No laila, hoʻohui hou kēia haʻawina i ke kumu e makaʻala ai i ka lawe ʻana i ka fructose i ka meaʻai, e pili ana i kona hopena ma ka ʻōnaehana pale.

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E hoʻomaopopo ':  

1. B Jones, N., Blagih, J., Zani, F. ¶ AL. Hoʻonohonoho hou ʻo Fructose i ka metabolism oxidative e pili ana i ka glutamine e kākoʻo i ka mumū i hoʻoiho ʻia e LPS. Nat Commun 12, 1209 (2021). https://doi.org/10.1038/s41467-021-21461-4 

2. Lā, SZ, Empie, MW Fructose metabolism i loko o ke kanaka - he aha nā haʻawina isotopic tracer e haʻi mai iā mākou. E hānai Metab (Lana) 9, 89 (2012). https://doi.org/10.1186/1743-7075-9-89 

3. Karlmark, KR, Tacke, F., & Dunay, IR (2012). Monocytes i ke olakino a me ka maʻi - Minireview. ʻO ka puke pai ʻEulopa o ka microbiology & immunology, 2(2), 97-102. https://doi.org/10.1556/EuJMI.2.2012.2.1 

4. ʻO Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. Niu Ioka: Garland Science; 2002. Innate Immunity. Loaʻa mai: https://www.ncbi.nlm.nih.gov/books/NBK26846/ 

5. Speakman J., 2003. Oxidative phosphorylation, mitochondrial proton cycling, free-radical production and aging. ʻO nā holomua ma ka Cell Aging and Gerontology. Volume 14, 2003, ʻaoʻao 35-68. DOI: https://doi.org/10.1016/S1566-3124(03)14003-5  

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