Hōʻike ka haʻawina i kahi hana hou e pili ana i ka holomua ʻana o ka maʻi ʻaʻai momona ʻole a hōʻike i ka protein Mitofusin 2 e like me ka hiki ke lilo i kumu hoʻohālike hiki ke mālama ʻia.
ʻO ka maʻi ʻona momona ʻole ka maʻi akepaʻa maʻamau e hoʻopilikia i ka poʻe inu ʻole a inu iki paha i ka waiʻona. Hoʻopilikia ia i 25 pakeneka o ka heluna kanaka o ka honua a ua laha loa ia ma nā ʻāina i hoʻomohala ʻia. Hōʻike ʻia ke ʻano me ka hōʻiliʻili ʻana o ka momona keu i loko o nā hunaola akepaʻa e alakaʻi ana i nā hana ʻino like ʻole o ke akepaʻa. He paʻakikī ke ʻike i kēia ʻano i ka wā mua. ʻAʻohe lāʻau lapaʻau i loaʻa no ka maʻi akepaʻa momona ʻole a ʻōlelo pinepine nā kauka e hoʻemi i ke kaumaha. I kahi ʻano koʻikoʻi o kēia maʻi i kapa ʻia ʻo non-alcoholic steatohepatitis (NASH), hele pū ka hōʻiliʻili ʻana o ka momona me ka mumū, ka make ʻana o nā cell a me ka fibrosis.
Ua hāpai ʻia kahi noiʻi i paʻi ʻia ma Cell ma Mei 2, 2019 i kahi pahuhopu therapeutic hou no ka mālama ʻana i ka maʻi momona ate ʻole . Ua ʻike nā kānaka noiʻi i kahi protein mitochondrial i kapa ʻia ʻo Mitofusin 2 hiki ke lilo i kekahi o nā kumu e hiki ai ke hāʻawi i ka pale ʻana i kēia kūlana. I kā lākou noiʻi ua ʻike lākou ua ʻike ʻia nā pae o ka protein Mitofusin 2 he haʻahaʻa i nā poʻe maʻi e loaʻa ana i ka NASH e like me ka ʻike ʻia mai kā lākou biopsies ate . Loaʻa nā pae haʻahaʻa i nā pae mua o NASH e hōʻike ana e ulu ana kēia maʻi i ka wā e emi ai ka protein Mitofusin 2 i loko o nā cell ate. Ua ʻike ʻia kahi hiʻohiʻona like i loko o nā cell ate o kahi kumu hoʻohālike ʻiole o ka maʻi momona ate ʻole . I loko o nā ʻiole, ʻo ka emi ʻana o nā pae o Mitofusin 2 ke kuleana no ka mumū ate, ka metabolism lipid maʻamau, ka fibrosis ate a me ke kanesa ate.
Ma nā hoʻokolohua i hana ʻia ma ke ʻano ʻiole o NASH, ua hoʻokomo ʻia nā ʻiole ma lalo o kahi meaʻai chow no 2 pule a ua hoʻokomo ʻia nā adenoviruses e hoʻopili ana i ka protein Mitofusin 2 i loko o ka ʻiole. Ua hoʻololi maoli ʻia ka maʻi virus e hōʻike artificial i nā protein. Ua nānā ʻia nā ake o kēia mau ʻiole ma hope o 1 pule. Ua hōʻike ʻia nā hopena i ʻike ʻia ke kūlana o NASH e hoʻomaikaʻi i nā ʻiole me ka hoʻomaikaʻi nui ʻana i ka lipid metabolism.
Ua hōʻike ʻia nā hoʻokolohua kikoʻī e pili pololei ana ka protein membrane ʻo Mitofusin 2 a kōkua i ka hoʻoili ʻana o ka phosphatidylserine (PS) i hana nui ʻia i loko o ka endoplasmic reticulum (ER). Hoʻopuka ʻo Mitofusin 2 i ka PS i loko o nā membrane e ʻae ana i ka hoʻoili ʻana o PS i mitochondria kahi i hoʻololi ʻia ai ka PS i phosphatidylethanolamine (PE) e hoʻouna ʻia i ER no ka hana ʻana i ka phosphatidylcholine. ʻO ka hemahema o Mitofusin 2 ke kumu o ka emi ʻana o ka hoʻoili ʻana o PS mai ER i mitochondria e hoʻopilikia ana i ka metabolism lipid. ʻO kēia hoʻoili hemahema e alakaʻi ai i ke kaumaha ER a hoʻoulu i nā hōʻailona like me NASH a me ka maʻi ʻaʻai. Ua maopopo ua hoʻemi ʻia ka hepatic Mitofusin 2 i loko o ke ake kanaka i ka wā o ka holomua mai ka steatosis maʻalahi i NASH. Hōʻike ka haʻawina i kahi hana hou o Mitofusin 2 i ka mālama ʻana i ka metabolism phospholipid. He mea nui loa ka pilina ma waena o Mitofusin 2 a me nā phospholipids no ka mea hiki i kēia ke hoʻohuli i nā waiwai antioxidant, anti-inflammatory, anti-fibrotic a me kekahi mau hana e pili ana i ka membrane. Ua hoʻomaikaʻi ka hoʻopuka hou ʻana o Mitofusin 2 i nā ʻiole ma ka papaʻai chow i ka maʻi akepaʻa.
Ke wehewehe nei ke aʻo ʻana i kēia manawa i kahi ʻano hana hou i hōʻike ʻole ʻia ma mua no ka hoʻomohala ʻana o ka maʻi akepaʻa momona ʻole-waiʻona a hōʻike i ka protein Mitofusin 2 ma ke ʻano he pahuhopu therapeutic hou no ka mālama ʻana i ka maʻi akepaʻa momona ʻole-waiʻona . E kālele ana nā haʻawina e hiki mai ana i nā ʻano hana like ʻole e hiki ai ke hoʻonui i nā pae o Mitofusin 2 me ka ʻole o ka hopena i nā hopena ʻaoʻao.
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Puna (s)
ʻO Hernández-Alvarez MI. et al. 2019. ʻO ka hoʻoili ʻana o ka Endoplasmic Reticulum-Mitochondrial Phosphatidylserine i nele i ke kumu o ka maʻi ate. Kelepona, 177 (4). https://doi.org/10.1016/j.cell.2019.04.010
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