Ua hōʻike ʻia nā haʻawina māhoe hou i nā ala hou o ka hana hou ʻana i ka puʻuwai ʻeha
Hoʻopilikia ka puʻuwai puʻuwai ma kahi o 26 miliona mau kānaka a puni ka honua a ʻo ia ke kuleana no ka nui o nā make make. Ma muli o ka piʻi ʻana o ka poʻe ʻelemakule, mālama i ka Puʻuwai ke lilo nei i mea e pono ai ke piʻi aʻe o nā lilo. Loaʻa nā holomua nui i nā lāʻau lapaʻau no ka Puʻuwai a ke hana ʻia nei nā hana pale he nui, akā naʻe, ʻoi aku ka nui o ka make a me ka maʻi maʻi. Loaʻa nā koho lapaʻau liʻiliʻi a ʻo ka hapa nui e kau ʻia ma ka hoʻololi ʻana i ka puʻuwai no nā poʻe maʻi i ka pae hope loa a ke holomua nei i ka pau ʻole o ka naʻau.
Loaʻa i ko mākou kino ka mana kupaianaha e ho'ōla iā ia iho, no ka laʻana hiki ke hana hou ʻia ke akepaʻa i ka wā i poino ʻia, ʻo ko mākou ʻili hoʻi i ka hapa nui o ka manawa a hiki i hoʻokahi puʻupaʻa ke lawe i ka hana no ʻelua. ʻO ka mea pōʻino, ʻaʻole ʻoiaʻiʻo kēia no ka hapa nui o ko mākou mau kino koʻikoʻi - me ka puʻuwai. Ke pōʻino ka naʻau o ke kanaka - ma muli o ka maʻi a i ʻole ka ʻeha - mau loa ka pōʻino. ʻO ka laʻana, ma hope o ka hōʻeha ʻana i ka naʻau, hiki i nā miliona a i ʻole nā piliona o nā ʻiʻo ʻiʻo puʻuwai e nalowale mau loa. Na kēia poho e hoʻonāwaliwali i ka puʻuwai a alakaʻi i nā kūlana koʻikoʻi e like me ka pau ʻole o ka naʻau, a i ʻole nā ʻeha o ka puʻuwai e hiki ke hōʻeha. ʻO ka pau ʻana o ka naʻau ka hopena i ka wā e nele ai nā cardiomyocytes (ʻano o nā cell). ʻAʻole like me nā mea hou a me nā salamanders, ʻaʻole hiki i nā poʻe makua kanaka ke hoʻoulu hou i nā kino i hōʻino ʻia e like me ka puʻuwai. I loko o kahi embryo kanaka a i ka wā e ulu ana ka pēpē i loko o ka ʻōpū, Puʻuwai puunaue a hoonui i ka puuwai e ulu a ulu no eiwa mahina. Akā, ʻaʻole i loaʻa i nā mammals me nā kānaka ka hiki ke hoʻōla hou i ka naʻau ke nalowale lākou i kēia hiki ma hope a ma hope o hoʻokahi pule o ka hānau ʻana. Nalo nā pūnaʻi ʻiʻo puʻuwai i ko lākou hiki ke puʻunaue a hoʻonui a no laila ʻaʻole hiki ke hana hou. He ʻoiaʻiʻo nō kēia no nā cell kanaka ʻē aʻe - ka lolo, ka lāʻauʻala a pela aku, no ka hiki ole i keia mau keena kanaka makua ke mahele, aole hiki i ke kino o ke kanaka ke pani i na keena i poino a nalowale, a ke alakai nei keia i na ma'i. ʻOiai ʻo ia ke kumu ʻaʻole loa he puʻuwai puʻuwai - ke kumu o nā maʻi koko ma muli o ka ulu ʻole ʻana o nā cell. Inā naʻe, hiki ke hoʻokaʻawale hou ʻia kēia mau cell, hiki i kēia ke alakaʻi i ka "hana hou" o kekahi mau kiko a kōkua i ka hoʻoponopono ʻana i kahi okana.
Hoʻokahi wale nō koho i loaʻa i kekahi ke loaʻa i ka nāwaliwali a i ʻole puuwai poino a i ʻole he maʻi puʻuwai ka loaʻa ʻana o kahi hoʻololi naʻau. Loaʻa kēia i nā ʻano he nui e pili ana i kahi transplant mai ka lilo ʻana i mea maoli i ka hapa nui o nā maʻi. ʻO ka mea mua, ʻo ka puʻuwai i hāʻawi ʻia e ka "mea hāʻawi" pono he puʻuwai olakino ma mua o ka hala ʻana o ka mea hāʻawi, ʻo ia hoʻi, pono e ʻohi ʻia ka puʻuwai mai nā poʻe ʻōpio i make no ka maʻi a i ʻole nā ʻeha a ʻaʻole i pili kēia mau ʻano i ko lākou Puʻuwai ma kekahi ano. Pono ka mea maʻi e loaʻa i ka mea maʻi me ka puʻuwai hāʻawi no ka loaʻa ʻana o ka transplant. Hoʻololi kēia i kahi kali lōʻihi. Ma ke ʻano he koho ʻē aʻe, hiki i ka hiki ke hana i nā ʻiʻo hou i loko o ka puʻuwai ma o ka mahele cell hiki ke hāʻawi i ka manaʻolana i nā miliona me ka puʻuwai ʻeha. Nui nā kaʻina hana i hoʻāʻo ʻia e ka ʻepekema ʻepekema, akā naʻe, ʻaʻole i kūpono nā hopena i kēia manawa.
Ma kahi noiʻi hou i paʻi ʻia ma 'Ola, ʻO nā mea noiʻi ma ke Kulanui o Kaleponi, San Francisco, USA no ka manawa mua i hoʻomohala i kahi ala kūpono a paʻa i nā ʻano holoholona e hoʻokaʻawale i nā puʻuwai makua (cardiomyocytes) a no laila hiki ke hoʻoponopono i ka ʻāpana ʻeha o ka puʻuwai.1. Ua ʻike nā mea kākau i ʻehā mau genes e pili ana i ka mahele cell (ʻo ia nā cell e hoʻonui i ko lākou iho). I ka hui ʻana o kēia mau genes me nā genes e hoʻokomo hou i nā cardiomyocytes makua i loko o kahi pōʻai cell, ʻike lākou e māhele ana a hana hou nā cell. No laila, i ka wā i hoʻonui ʻia ai ka hana o kēia mau genes pono ʻehā, ʻo ka Puʻuwai hōʻike hou ʻia ka ʻiʻo. Ma hope o ka pau ʻole o ka naʻau i ka mea maʻi, hoʻomaikaʻi kēia hui ʻana i ka hana naʻau. Ua hōʻike ʻo Cardiomyocytes i ka māhele 15-20 pakeneka i ka haʻawina o kēia manawa (i hoʻohālikelike ʻia me 1 pākēneka i nā haʻawina mua) e hoʻomaʻamaʻa i ka hilinaʻi a me ka pono o kēia haʻawina. Hiki ke hoʻonui ʻia kēia haʻawina i nā ʻano ʻē aʻe no ka mea he hiʻohiʻona maʻamau kēia mau genes ʻehā. He hana kūpono loa kēia no ka mea, ʻo kēlā me kēia haʻawina ma ka Puʻuwai ʻO ka mua he paʻakikī loa a ʻo ka lua, pono e hana ʻia ka lawe ʻana i nā genes me ka akahele i ʻole e hoʻokumu ʻia i nā maʻi koko i loko o ke kino. Hiki i kēia hana ke lilo i ala ikaika loa no ka ho'ōla hou ʻana i ka puʻuwai a me nā mea ʻē aʻe.
ʻO kekahi haʻawina e Stem Cell Institute, University of Cambridge, UK, ua hoʻomohala i kahi ala hou e hoʻoponopono ai Puʻuwai ʻiʻo i ʻole e koi ʻia kahi mea hāʻawi2. Ua hoʻohana lākou i nā pūnaewele kumu no ka ulu ʻana i nā ʻāpana ola o ka "ʻiʻo puʻuwai" i loko o ke keʻena hana he 2.5 kenimika square wale nō akā ua like lākou me kahi mea hana ikaika e mālama ai i nā poʻe maʻi i loaʻa ʻole ka puʻuwai. Loaʻa i kēia mau patches kahi manaʻo maikaʻi e komo maoli i loko o kahi mea maʻi Puʻuwai ʻo ia hoʻi, he ʻiʻo "hana piha" e kuʻi a ʻaelike e like me ka ʻiʻo puʻuwai maʻamau. ʻAʻole i kūleʻa kahi ala mua o ka hoʻokomo ʻana i nā pūnaewele kumu i loko o ke kino no ka hoʻoponopono ʻana i ka puʻuwai no ka mea ʻaʻole i noho nā pūnaʻi pū i loko o ke kino. Puʻuwai ʻiʻo akā ua nalowale i loko o ke koko. ʻO ka pāpaʻi o kēia manawa he ʻiʻo puʻuwai "ola" a "paʻi" i hiki ke hoʻopili ʻia i kahi okana (ma kēia hihia ka Puʻuwai) a no laila hiki ke hoʻoponopono ʻia kekahi pōʻino. Hiki ke hoʻonui ʻia ia mau ʻāpana i ka wā e koi ʻia ai ka mea maʻi. E ʻoi aku kēia ma mua o ka pono e kali i kahi mea hāʻawi like. Hiki ke hoʻonui ʻia kēia mau ʻāpana me ka hoʻohana ʻana i ka Puʻuwai nā pūnaewele ponoʻī o ka mea maʻi e hoʻopau ana i nā pilikia e pili ana i ka hoʻololi ʻana o ke kino. ʻO ka hoʻohui ʻana i ka pā i loko o a puuwai poino He kaʻina hana invasive a koi i nā manaʻo uila pololei no ka hana ʻana i ka Puʻuwai kuʻi i hoʻohui maikaʻi ʻia me kahi pā. Akā ʻoi aku ka maikaʻi o nā pilikia i loko o kēia ʻano kaʻina hana ma mua o ka hoʻololi ʻana i ka puʻuwai holoʻokoʻa i ʻoi aku ka invasive. Ke mākaukau nei ka hui no nā hoʻokolohua holoholona a me nā hoʻokolohua lapaʻau i loko o 5 mau makahiki ma mua o ka hiki ke hoʻohana nui ʻia Puʻuwai maʻi.
***
Puna (s)
1. Mohamed et al. 2018,. Hoʻoponopono i ka pōʻaiapili pūnaewele no ka hoʻouluʻana i ka hoʻonuiʻana o ka maʻi cardiomyocyte a me ka hana houʻana o ka naʻau. Cell. https://doi.org/10.1016/j.cell.2018.02.014
2. Ke Kulanui o Cambridge 2018. Patching up a broken heart. http://www.cam.ac.uk/research/features/patching-up-a-broken-heart. [Loaʻa iā Mei 1 2018]
***
